Two mechanisms of somatic hypermutation of Ig V genes

T. Dorner, N. L. Farner, P. E. Lipsky

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


There is currently a debate as to whether transcription and/or replication are linked to the process of somatic hypermutation of Ig V regions. Here, T. Dorner, N.L. Farner, and Peter E. Lipsky look at the current data and propose that two mechanisms are possible, one of which is dependent on mismatch repair (MMR) proteins and replication, and a second which is independent of these.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
Issue number5
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Immunology
  • Cell Biology


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