Two-dimensional contrast echocardiography in the detection and follow-up of congenital pulmonary arteriovenous malformations

Benico Barzilai, Alan D. Waggoner, Cheryl Spessert, Daniel Picus, Daniel Goodenberger

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146 Scopus citations


Pulmonary arteriovenous (A-V) malformation is frequently a manifestation of Osler-Weber-Rendu syndrome (hereditary hemorrhagic telangiectasia). We identified 14 patients (9 men and 5 women) with A-V malformation by contrast echocardiography; 10 patients with atrial right-to-left shunt served as control subjects. Agitated saline solution (10 ml) was injected through a peripheral vein during echocardiographic imaging. The delay in the appearance of microcavitations in the left atrium was measured (in number of frames) after right atrial appearance. The degree of left ventricular opacification was graded 1 to 4+ (where 4+ = intense left ventricular endocardial outline, and 1+ = minimal opacification). Results indicated patients with A-V malformation had a significant delay (p < 0.001) in left atrial appearance of microcavitations compared with those with atrial right-to-left shunt (66 ± 27 vs 21 ± 7 frames, mean ± 1 standard deviation). In the group with A-V malformation, abnormal blood gases were present in only 6 of 14 patients and chest x-ray was positive in 7. Pulmonary angiography was performed in 11 of 14 patients with positive contrast echocardiography, and all 11 had A-V malformation identified. In patients with 3 to 4+ left ventricular opacification (n = 8), large (>5 mm feeding vessel) or multiple malformations were present, whereas patients with small or isolated malformation had 1 to 2+ left ventricular opacification. Balloon occlusion of malformations was performed in all 11 of these patients; repeat contrast echocardiography revealed significant diminution of right-to-left shunt in 9, and 2 required repeat embolotherapy for an additional previously undetected A-V malformation. Thus, contrast 2-dimensional echocardiography is extremely sensitive for the identification of pulmonary A-V malformation.

Original languageEnglish (US)
Pages (from-to)1507-1510
Number of pages4
JournalThe American journal of cardiology
Issue number15
StatePublished - Dec 1 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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