TY - JOUR
T1 - Tumor Vascularity in Renal Masses
T2 - Correlation of Arterial Spin-Labeled and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Assessments
AU - Zhang, Yue
AU - Kapur, Payal
AU - Yuan, Qing
AU - Xi, Yin
AU - Carvo, Ingrid
AU - Signoretti, Sabina
AU - Dimitrov, Ivan
AU - Cadeddu, Jeffrey A
AU - Margulis, Vitaly
AU - Muradyan, Naira
AU - Brugarolas, James B
AU - Madhuranthakam, Ananth J
AU - Pedrosa, Ivan
N1 - Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background The objective of this study was to investigate potential correlations between perfusion using arterial spin-labeled (ASL) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE) MRI-derived quantitative measures of vascularity in renal masses > 2 cm and to correlate these with microvessel density (MVD) in clear cell renal cell carcinoma (ccRCC). Patients and Methods Informed written consent was obtained from all patients before imaging in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, prospective study. Thirty-six consecutive patients scheduled for surgery of a known renal mass > 2 cm underwent 3T ASL and DCE MRI. ASL perfusion measures (PASL) of mean, peak, and low perfusion areas within the mass were correlated to DCE-derived volume transfer constant (Ktrans), rate constant (Kep), and fractional volume of the extravascular extracellular space (Ve) in the same locations using a region of interest analysis. MRI data were correlated to MVD measures in the same tumor regions in ccRCC. Spearman correlation was used to evaluate the correlation between PASL and DCE-derived measurements, and MVD. P <.05 was considered statistically significant. Results Histopathologic diagnosis was obtained in 36 patients (25 men; mean age 58 ± 12 years). PASL correlated with Ktrans (ρ = 0.48 and P =.0091 for the entire tumor and ρ = 0.43 and P =.03 for the high flow area, respectively) and Kep (ρ = 0.46 and P =.01 for the entire tumor and ρ = 0.52 and P =.008 for the high flow area, respectively). PASL (ρ = 0.66; P =.0002), Ktrans (ρ = 0.61; P =.001), and Kep (ρ = 0.64; P =.0006) also correlated with MVD in high and low perfusion areas in ccRCC. Conclusion PASL correlated with the DCE-derived measures of vascular permeability and flow, Ktrans and Kep, in renal masses > 2 cm in size. Both measures correlated to MVD in clear cell histology.
AB - Background The objective of this study was to investigate potential correlations between perfusion using arterial spin-labeled (ASL) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE) MRI-derived quantitative measures of vascularity in renal masses > 2 cm and to correlate these with microvessel density (MVD) in clear cell renal cell carcinoma (ccRCC). Patients and Methods Informed written consent was obtained from all patients before imaging in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, prospective study. Thirty-six consecutive patients scheduled for surgery of a known renal mass > 2 cm underwent 3T ASL and DCE MRI. ASL perfusion measures (PASL) of mean, peak, and low perfusion areas within the mass were correlated to DCE-derived volume transfer constant (Ktrans), rate constant (Kep), and fractional volume of the extravascular extracellular space (Ve) in the same locations using a region of interest analysis. MRI data were correlated to MVD measures in the same tumor regions in ccRCC. Spearman correlation was used to evaluate the correlation between PASL and DCE-derived measurements, and MVD. P <.05 was considered statistically significant. Results Histopathologic diagnosis was obtained in 36 patients (25 men; mean age 58 ± 12 years). PASL correlated with Ktrans (ρ = 0.48 and P =.0091 for the entire tumor and ρ = 0.43 and P =.03 for the high flow area, respectively) and Kep (ρ = 0.46 and P =.01 for the entire tumor and ρ = 0.52 and P =.008 for the high flow area, respectively). PASL (ρ = 0.66; P =.0002), Ktrans (ρ = 0.61; P =.001), and Kep (ρ = 0.64; P =.0006) also correlated with MVD in high and low perfusion areas in ccRCC. Conclusion PASL correlated with the DCE-derived measures of vascular permeability and flow, Ktrans and Kep, in renal masses > 2 cm in size. Both measures correlated to MVD in clear cell histology.
KW - Angiogenesis
KW - Arterial spin labeling
KW - Dynamic contrast-enhanced MRI
KW - Kidney cancers
KW - Microvessel density
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U2 - 10.1016/j.clgc.2015.08.007
DO - 10.1016/j.clgc.2015.08.007
M3 - Article
C2 - 26422014
AN - SCOPUS:84951745305
SN - 1558-7673
VL - 14
SP - e25-e36
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
IS - 1
ER -