Abstract
We recently demonstrated that C-CAM, an epithelial-cell adhesion molecule of the immunoglobulin supergene family, could be regulated by androgen and might act as a growth repressor during differentiation of the prostatic epithelium. To define the role of C-CAM in prostatic tumor-igenesis, a tumorigenic human prostatic cancer cell line, PC-3, was trans-fected with an expression plasmid containing C-CAM1 (a C-CAM isoform). Transfected clones showed significantly lower growth rates, reduced anchorage-independent growth, and less tumorigenicity in vivo than control cells. Furthermore, transfection of an antisense vector into a nontumorigenic prostatic epithelial cell line, NbE, resulted in tumor formation in nude mice. Sublines derived from these NbE-induced tumors had lower levels of C-CAM than did control cells. These data suggest that C-CAM1 can function as a tumor suppressor in prostate tumorigenesis.
Original language | English (US) |
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Pages (from-to) | 190-197 |
Number of pages | 8 |
Journal | Cancer research |
Volume | 55 |
Issue number | 1 |
State | Published - Jan 1 1995 |
ASJC Scopus subject areas
- Oncology
- Cancer Research