Tumor perfusion and neovascular morphology measurements using dynamic contrast-enhanced ultrasound imaging

Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


A novel image processing strategy is introduced for the measurement of tumor perfusion and neovascular morphology parameters from a sequence of dynamic contrast-enhanced ultrasound (DCE-US) images. A computationally efficient technique for locally mapping tumor perfusion parameters using skeletonized neovascular data is also introduced. Longitudinal DCE-US image datasets were collected in breast cancer patients before and after initiation neoadjuvant chemotherapy. Preliminary findings suggest that breast tumor response to neoadjuvant chemotherapy is characterized in part by considerable changes in intratumoral perfusion parameters. Moreover, it was also revealed that DCE-US-based neovascular morphology parametric measures also exhibit pronounced changes that may be predictive of breast tumor response to systemic treatment as determined from surgical specimens. Breast cancer management from early detection to therapeutic monitoring is currently undergoing profound changes. The development of novel imaging techniques that are sensitive to the unique biological conditions of each individual tumor represent valuable tools in the pursuit of personalize medicine.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)9781479970490
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


Other2014 IEEE International Ultrasonics Symposium, IUS 2014
Country/TerritoryUnited States


  • angiogenesis
  • breast cancer
  • contrast agent
  • microbubbles
  • ultrasound
  • vascular morphology

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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