TY - JOUR
T1 - Tumor hypoxia
T2 - From basic knowledge to therapeutic implications
AU - Liao, Chengheng
AU - Liu, Xijuan
AU - Zhang, Cheng
AU - Zhang, Qing
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/1
Y1 - 2023/1
N2 - Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most common characteristics of cancer. Hypoxia shapes the landscape of the tumor microenvironment (TME) into a pro-tumorigenic and pro-metastatic niche through arrays of pathological alterations such as abnormal vasculature, altered metabolism, immune-suppressive phenotype, etc. In addition, emerging evidence suggests that limited efficacy or the development of resistance towards antitumor therapy may be largely due to the hypoxic TME. This review will focus on summarizing the knowledge about the molecular machinery that mediates the hypoxic cellular responses and adaptations, as well as highlighting the effects and consequences of hypoxia, especially for angiogenesis regulation, cellular metabolism alteration, and immunosuppressive response within the TME. We also outline the current advances in novel therapeutic implications through targeting hypoxia in TME. A deep understanding of the basics and the role of hypoxia in the tumor will help develop better therapeutic avenues in cancer treatment.
AB - Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most common characteristics of cancer. Hypoxia shapes the landscape of the tumor microenvironment (TME) into a pro-tumorigenic and pro-metastatic niche through arrays of pathological alterations such as abnormal vasculature, altered metabolism, immune-suppressive phenotype, etc. In addition, emerging evidence suggests that limited efficacy or the development of resistance towards antitumor therapy may be largely due to the hypoxic TME. This review will focus on summarizing the knowledge about the molecular machinery that mediates the hypoxic cellular responses and adaptations, as well as highlighting the effects and consequences of hypoxia, especially for angiogenesis regulation, cellular metabolism alteration, and immunosuppressive response within the TME. We also outline the current advances in novel therapeutic implications through targeting hypoxia in TME. A deep understanding of the basics and the role of hypoxia in the tumor will help develop better therapeutic avenues in cancer treatment.
KW - Angiogenesis
KW - Hypoxia
KW - Hypoxia-inducible factors
KW - Immunotherapy
KW - Metabolism
KW - Tumor microenvironment
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U2 - 10.1016/j.semcancer.2022.12.011
DO - 10.1016/j.semcancer.2022.12.011
M3 - Review article
C2 - 36603793
AN - SCOPUS:85146074804
SN - 1044-579X
VL - 88
SP - 172
EP - 186
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -