Tumor dormancy has been well recognized clinically (1-5) but there is a paucity of experimental studies (6-14) concerning this important aspect of host-tumor interaction. Early in our investigations of a murine lymphoma/1eukemia (BCL1) we encountered dormancy. BCL1 was the first B cell lymphoma described in mice (15). It arose spontaneously in a two-year old BALB/c mouse and is characterized by early and massive enlargement of the spleen followed later by leukemia and infiltration of the liver. The clinical characteristics of BCL1 resemble the prolymphocytic form of chronic lymphocytic leukemia in humans (16). The tumor cells express IgMλ and IgDλ; these two isotypes share a common idiotype (Id) which has been defined both serologically and by sequence analysis (17). This is an attractive model for the study of dormancy because the immunoglobulin Id is a clonal marker; the DNA VH region gene rearrangements will facilitate detection of minimal disease by polymerase chain reaction; the tumor grows rapidly and primarily in the spleen so that tumor growth can be followed by palpation; and tumor cells can also be quantified by both Id-analysis and transfer of graded number of splenocytes from tumor bearing animals to syngeneic recipients. A single BCL1 cell can transfer tumor to a naive animal (16).
ASJC Scopus subject areas
- Immunology and Microbiology(all)