Trks: Signal transduction and intracellular pathways

Laura J. Klesse, Luis F. Parada

Research output: Contribution to journalArticlepeer-review

139 Scopus citations


The neurotrophin family of growth factors supports survival and differentiation of neurons in the developing vertebrate nervous system by binding activating receptor tyrosine kinases, the Trks. Activation of Trk receptors leads to stimulation of a number of intracellular signaling cascades including, among others, the ras/extracellular regulated kinase (erk) and the phosphatidylinositol-3 kinase (PI 3 kinase) cascades. Over the past several years, work in several neurotrophin responsive systems has begun to identify the role each of these signaling cascades plays in the cellular response to neurotrophins. It now appears that neurotrophins, in particular nerve growth factor (NGF), mediate their multiple effects through a number of distinct intracellular signaling cascades. In this review, we will overview the evidence implicating specific signaling cascades in aspects of the cellular response to the neurotrophins, specifically in response to activation of TrkA by NGF.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalMicroscopy Research and Technique
Issue number4-5
StatePublished - May 15 1999


  • Nerve growth factor
  • Neurons
  • PC12 cells
  • PI 3 kinase
  • Ras

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology


Dive into the research topics of 'Trks: Signal transduction and intracellular pathways'. Together they form a unique fingerprint.

Cite this