TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease

Medicine & Life Sciences

• 6,7-dihydroxyflavone 100%
• alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 68%
• Spatial Memory 60%
• Receptor Protein-Tyrosine Kinases 59%
• Memory Disorders 58%
• Synapses 50%
• Alzheimer Disease 42%
• AMPA Receptors 32%
• Calcium-Calmodulin-Dependent Protein Kinase Type 2 17%
• Amyloid beta-Protein Precursor 15%
• cyclotraxin-B 15%
• Phosphorylation 14%
• AMPA 1 glutamate receptor ionotropic 11%
• KN 93 11%
• Memory 10%
• Isoxazoles 9%
• propionic acid 9%
• Serum Amyloid A Protein 9%
• Fragile X Syndrome 8%
• Cyclic AMP Response Element-Binding Protein 8%
• U 0126 8%
• Wortmannin 8%
• Neurotransmitter Receptor 8%
• MAP Kinase Signaling System 7%
• Dendrites 7%
• Amyloid 6%
• Transgenic Mice 6%
• Oral Administration 5%
• Hippocampus 5%
• Learning 5%
• Aptitude 4%
• Brain 3%
• Proteins 2%

Chemical Compounds

• Tyrosine 50%
• KN-93 23%
• U0126 21%
• Wortmannin 18%
• Pathway Inhibitor 18%
• Protein 18%
• Agonist 10%
• Acid 3%
• Surface 3%
• Application 3%