TY - JOUR
T1 - Trending
T2 - Radioactive and fluorescent bimodal/hybrid tracers as multiplexing solutions for surgical guidance
AU - van Leeuwen, Fijs W.B.
AU - Schottelius, Margret
AU - Brouwer, Oscar R.
AU - Vidal-Sicart, Sergi
AU - Achilefu, Samuel
AU - Klode, Joachim
AU - Wester, Hans Jurgen
AU - Buckle, Tessa
N1 - Publisher Copyright:
COPYRIGHT © 2020 by the Society of Nuclear Medicine and Molecular Imaging.
PY - 2020/1
Y1 - 2020/1
N2 - By contributing to noninvasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade, it has also become apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help to empower fluorescence-guided surgery. More specifically, when using hybrid tracers, lesions can be noninvasively identified and localized with a high sensitivity and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions, and key aspects that could have an impact on the future of this field.
AB - By contributing to noninvasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade, it has also become apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help to empower fluorescence-guided surgery. More specifically, when using hybrid tracers, lesions can be noninvasively identified and localized with a high sensitivity and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions, and key aspects that could have an impact on the future of this field.
KW - Bimodal tracers
KW - Fluorescence imaging
KW - Image-guided surgery
KW - Multimodal
KW - Nuclear medicine
UR - http://www.scopus.com/inward/record.url?scp=85077477132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077477132&partnerID=8YFLogxK
U2 - 10.2967/jnumed.119.228684
DO - 10.2967/jnumed.119.228684
M3 - Article
C2 - 31712326
AN - SCOPUS:85077477132
SN - 0161-5505
VL - 61
SP - 13
EP - 19
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 1
ER -