Treatment strategies for the prevention of heart failure

Justin L. Grodin, W. H Wilson Tang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


With the astounding morbidity and mortality associated with heart failure (HF), preventive approaches have been explored. Controlling hypertension to prevent HF is well-established, especially with sodium restriction and thiazide-based antihypertensive therapies showing potential advantages. Control of dyslipidemia with aggressive statin therapy is particularly beneficial in preventing HF in the setting of acute coronary syndrome. The HOPE study also established the benefit of ACE inhibitors in the prevention of HF in high-risk subjects. Meanwhile old data supporting tight glycemic control in preventing HF have not been confirmed, suggesting the complexity of diabetic cardiomyopathy. Avoiding tobacco use and other known cardiotoxins are likely helpful. While there has been substantial development in identifying biomarkers predicting future development of HF, therapeutic interdiction guided by biomarker levels have yet to be established, even though it offers hope in modulating the natural history of the development of HF in at-risk individuals.

Original languageEnglish (US)
Pages (from-to)331-340
Number of pages10
JournalCurrent heart failure reports
Issue number4
StatePublished - Dec 2013


  • Angiotensin converting enzyme inhibitor
  • Angiotensin receptor blocker
  • Beta-blocker
  • Biomarkers
  • Brain natriuretic peptide
  • Cardiomyopathy
  • Coronary artery disease
  • Diabetes mellitus
  • Heart failure
  • Hyperlipidemia
  • Hypertension
  • Insulin resistance
  • Left bundle branch block
  • Left ventricular hypertrophy
  • Obesity
  • Prevention
  • Statins
  • Thiazide diuretic
  • Troponin

ASJC Scopus subject areas

  • Emergency Medicine
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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