Treatment of vocal fold scarring: Rheological and histological measures of homologous collagen matrix

Kevin J. Kriesel, Susan L. Thibeault, Roger W. Chan, Tatsutoshi Suzuki, Patrick J. Vangroll, Diane M. Bless, Charles N. Ford

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The current treatment options for dysphonia secondary to vocal fold scarring are limited. Few studies address changes in the lamina propria, which is critical to vocal fold biomechanical properties and voice production. Using rheological and histological measures of homologous collagen matrix (HCM)-injected vocal folds, we assessed HCM's potential for providing bulk and restoring biomechanical performance. Twenty rabbits underwent bilateral vocal fold scarring. After 10 weeks of scar maturation, the rabbits had unilateral injections of HCM or saline solution. Ten weeks after the injections, histological studies revealed well-defined collagen globules distributed throughout the lamina propria and underlying muscular tissue. Significantly more procollagen was observed in the HCM-treated group. No significant differences in elastic shear modulus or dynamic viscosity were found between the treatment groups. This study demonstrates that HCM is an inert, relatively stable injectate that may serve well for medialization but does not appear to improve the dynamic properties of the lamina propria.

Original languageEnglish (US)
Pages (from-to)884-889
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Issue number10
StatePublished - Oct 1 2002


  • Collagen
  • Dynamic viscosity
  • Larynx
  • Procollagen
  • Rabbit
  • Scar
  • Shear modulus
  • Vocal fold

ASJC Scopus subject areas

  • Otorhinolaryngology


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