Treatment of Psychiatric Disorders in Chronic Kidney Disease Patients

Lucile Parker Gregg, S. Susan Hedayati

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Patients with chronic kidney disease (CKD) have a high rate of comorbid psychiatric conditions, including mood and anxiety disorders, substance use disorders, and eating disorders. Treatment of psychiatric disorders in CKD patients can be complicated by altered pharmacokinetics, unclear safety and efficacy of treatments, and lack of supporting evidence to guide treatment decisions. Furthermore, some psychiatric interventions may lead to renal complications, such as fluid and electrolyte disorders or worsening CKD. We review the evidence base regarding treatment of psychiatric disorders in CKD patients. We also present practical considerations regarding the management of psychiatric disorders in patients with CKD, including identifying candidates for therapy or mental health referral, the evidence for pharmacologic and nonpharmacologic therapy in CKD patients, the effects of CKD on psychiatric treatment, and consequences of these interventions that may prompt nephrology consultation.

Original languageEnglish (US)
Title of host publicationChronic Renal Disease
Number of pages18
ISBN (Electronic)9780128158760
ISBN (Print)9780128158777
StatePublished - Jan 1 2019


  • Depression
  • Pharmacokinetics
  • Psychiatric disorders
  • Psychopharmacology
  • Psychotherapy

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology


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