Treatment of Acute Otitis Media of Infancy With Cefaclor

J. D. Nelson, C. M. Ginsburgh, J. C. Clahsen, L. H. Jackson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The emergence of ampicillin-resistant Haemophilus as a clinical problem in otitis media necessitates a search for alternative, effective therapy. An orally absorbable cephalosporin derivative, cefaclor, is equally effective in vitro against ampicillin-susceptible and -resistant Haemophilus and against other bacteria that cause acute otitis media. Two dosage schedules of cefaclor (40 and 60 mg/kg/day) were evaluated in 95 infants with acute otitis media. Bacterial origin was determined by a culture of tympanocentesis fluid. Success rates using the smaller dosage were inferior to those using the larger dosage. Results of therapy for pneumococcal and Haemophilus infection with 60 mg/kg/day were comparable to those previously found with amoxicillin trihydrate or with combinations of trisulfapyrimadines with erythromycin or penicillin V. One patient with an ampicillin-resistant Haemophilus infection responded well to cefaclor and did not have a relapse. Cefaclor was well tolerated and caused an acceptably low incidence of minor, adverse effects. Cefaclor deserves further testing as a candidate for preferred status as a single-drug treatment of acute otitis media.

Original languageEnglish (US)
Pages (from-to)992-996
Number of pages5
JournalAmerican Journal of Diseases of Children
Issue number10
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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