Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia

Michael J.C. Bray, Lisa N. Richey, Barry R. Bryant, Akshay Krieg, Sahar Jahed, William Tobolowsky, Christian LoBue, Matthew E. Peters

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Introduction: Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians. Methods: Incidence of NPS was examined in participants with normal cognition who progressed to all-cause dementia based on whether TBI history was present (n = 130) or absent (n = 849). Survival analyses were used to examine NPS incidence across 7.6 ± 3.0 years of follow-up. Results: Participants with TBI history had increased prevalence and incidence of apathy (44.7% vs 29.9%, P =.0062; HRadj. = 1.708, P =.0018) and motor disturbances (17.2% vs 9.5%, P =.0458; HRadj. = 2.023, P =.0168), controlling for demographics and type of dementia diagnosis. Earlier anxiety onset was associated with TBI (692 days prior to dementia diagnosis vs 161 days, P =.0265). Discussion: History of TBI is associated with increased risk for and earlier onset of NPS in the trajectory of dementia development.

Original languageEnglish (US)
Pages (from-to)686-691
Number of pages6
JournalAlzheimer's and Dementia
Issue number4
StatePublished - Apr 2021


  • Alzheimer's disease
  • acquired brain injury
  • all-cause dementia
  • anxiety
  • apathy
  • dementia
  • geriatric psychiatry
  • mild behavioral impairment
  • motor disturbances
  • neurodegeneration
  • neuropsychiatric symptoms
  • neuropsychiatry
  • traumatic brain injury

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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