Abstract
As a unique type of glial cell in the olfactory system, olfactory ensheathing cells (OECs) are thought to be responsible for the successful regeneration of olfactory axons throughout the life of adult mammals. Because of their axonal growth-promoting properties, transplantation of OECs has been proposed as a promising experimental therapy for the treatment of neural injuries. Based on previous studies, several human clinical trials have been carried out to test the feasibility and safety of OEC transplantation for the treatment of central and peripheral nervous system lesions. This review provides an overview of the regeneration-promoting biological properties of OECs and of their therapeutic application in nervous system repair.
| Original language | English (US) |
|---|---|
| Title of host publication | Neural Regeneration |
| Publisher | Elsevier Inc. |
| Pages | 301-319 |
| Number of pages | 19 |
| ISBN (Print) | 9780128018347, 9780128017326 |
| DOIs | |
| State | Published - Feb 6 2015 |
Keywords
- Cell transplantation
- Neural injury
- Neural regeneration
- Neural repair
- Olfactory ensheathing cell
ASJC Scopus subject areas
- General Medicine