Transmission of antimicrobial-resistant staphylococcus aureus clonal complex 9 between pigs and humans, United States

Pranay R. Randad; Jesper Larsen; Hülya Kaya; Nora Pisanic; Carly Ordak; Lance B. Price; Maliha Aziz; Maya L. Nadimpalli; Sarah Rhodes; Jill R. Stewart; Dave C. Love; David Mohr; Meghan F. Davis; Lloyd S. Miller; Devon Hall; Karen C. Carroll; Trish M. Perl; Christopher D. Heaney

doi:10.3201/eid2703.191775

Transmission of antimicrobial-resistant staphylococcus aureus clonal complex 9 between pigs and humans, United States

Pranay R. Randad, Jesper Larsen, Hülya Kaya, Nora Pisanic, Carly Ordak, Lance B. Price, Maliha Aziz, Maya L. Nadimpalli, Sarah Rhodes, Jill R. Stewart, Dave C. Love, David Mohr, Meghan F. Davis, Lloyd S. Miller, Devon Hall, Karen C. Carroll, Trish M. Perl, Christopher D. Heaney

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHO) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0–34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.

Original language	English (US)
Pages (from-to)	740-748
Number of pages	9
Journal	Emerging Infectious Diseases
Volume	27
Issue number	3
DOIs	https://doi.org/10.3201/eid2703.191775
State	Published - Mar 2021

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Randad, P. R., Larsen, J., Kaya, H., Pisanic, N., Ordak, C., Price, L. B., Aziz, M., Nadimpalli, M. L., Rhodes, S., Stewart, J. R., Love, D. C., Mohr, D., Davis, M. F., Miller, L. S., Hall, D., Carroll, K. C., Perl, T. M., & Heaney, C. D. (2021). Transmission of antimicrobial-resistant staphylococcus aureus clonal complex 9 between pigs and humans, United States. Emerging Infectious Diseases, 27(3), 740-748. https://doi.org/10.3201/eid2703.191775

Randad, PR, Larsen, J, Kaya, H, Pisanic, N, Ordak, C, Price, LB, Aziz, M, Nadimpalli, ML, Rhodes, S, Stewart, JR, Love, DC, Mohr, D, Davis, MF, Miller, LS, Hall, D, Carroll, KC, Perl, TM & Heaney, CD 2021, 'Transmission of antimicrobial-resistant staphylococcus aureus clonal complex 9 between pigs and humans, United States', Emerging Infectious Diseases, vol. 27, no. 3, pp. 740-748. https://doi.org/10.3201/eid2703.191775

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abstract = "Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHO) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0–34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.",

author = "Randad, {Pranay R.} and Jesper Larsen and H{\"u}lya Kaya and Nora Pisanic and Carly Ordak and Price, {Lance B.} and Maliha Aziz and Nadimpalli, {Maya L.} and Sarah Rhodes and Stewart, {Jill R.} and Love, {Dave C.} and David Mohr and Davis, {Meghan F.} and Miller, {Lloyd S.} and Devon Hall and Carroll, {Karen C.} and Perl, {Trish M.} and Heaney, {Christopher D.}",

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AU - Randad, Pranay R.

AU - Larsen, Jesper

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AU - Pisanic, Nora

AU - Ordak, Carly

AU - Price, Lance B.

AU - Aziz, Maliha

AU - Nadimpalli, Maya L.

AU - Rhodes, Sarah

AU - Stewart, Jill R.

AU - Love, Dave C.

AU - Mohr, David

AU - Davis, Meghan F.

AU - Miller, Lloyd S.

AU - Hall, Devon

AU - Carroll, Karen C.

AU - Perl, Trish M.

AU - Heaney, Christopher D.

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N2 - Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHO) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0–34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.

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Transmission of antimicrobial-resistant staphylococcus aureus clonal complex 9 between pigs and humans, United States

Abstract

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