Translational efficacy of humanized exposures of cefepime, ertapenem, and levofloxacin against extended-spectrum-β-lactamase-producing Escherichia coli in a murine model of complicated urinary tract infection

Marguerite L. Monogue; David P. Nicolaua

doi:10.1128/AAC.01329-17

Translational efficacy of humanized exposures of cefepime, ertapenem, and levofloxacin against extended-spectrum-β-lactamase-producing Escherichia coli in a murine model of complicated urinary tract infection

Marguerite L. Monogue, David P. Nicolaua

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Validated animal models are required as bridging tools to assess the utility of novel therapies and potential microbiologic outcomes. Herein, we utilized uropathogenic extended-spectrum-β-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli in the neutropenic murine complicated urinary tract infection (cUTI) model with humanized exposures of cefepime, ertapenem, and levofloxacin to assess its translational value to human outcomes. Our data support the translational utility of this murine model to cUTI in humans as humanized exposures produced microbiologic outcomes consistent with the phenotypic profiles of the organisms.

Original language	English (US)
Article number	e01329-17
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01329-17
State	Published - Nov 2017
Externally published	Yes

Keywords

Cefepime
ESBL
Ertapenem
Escherichia coli
Levofloxacin
Urinary tract infection

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Translational efficacy of humanized exposures of cefepime, ertapenem, and levofloxacin against extended-spectrum-β-lactamase-producing Escherichia coli in a murine model of complicated urinary tract infection. / Monogue, Marguerite L.; Nicolaua, David P.
In: Antimicrobial agents and chemotherapy, Vol. 61, No. 11, e01329-17, 11.2017.

Research output: Contribution to journal › Article › peer-review

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Translational efficacy of humanized exposures of cefepime, ertapenem, and levofloxacin against extended-spectrum-β-lactamase-producing Escherichia coli in a murine model of complicated urinary tract infection

Abstract

Keywords

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