Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis

J. E. Rehg, B. A. Yarbrough, S. P. Pakes

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Lethal enterocolitis was induced in guinea pigs by intramuscular injection of penicillin. The presence of a filterable toxic substance in the cecal contents of penicillin-treated guinea pigs was demonstrated. The toxin was heat-labile and produced enterosorption activity in rabbit intestinal loops and morphologic changes in Y-1 adrenal cell cultures. The cecal filtrates were lethal for mice when injected intraperitoneally and lethal for guinea pigs when injected intraperitoneally or intracecally. Cecal filtrates from saline-treated guinea pigs were not lethal to experimental animals. Filtrates prepared from broth cultures of cecal contents from penicillin or saline-treated guinea pigs also showed the presence of a lethal toxic substance. This study demonstrated that bacteremia is minimal, nonspecific and probably a terminal event in penicillin-associated deaths in guinea pigs.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
Number of pages8
StatePublished - 1980

ASJC Scopus subject areas

  • General Medicine


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