Total synthesis of (±)-welwitindolinone A isonitrile

Sarah E. Reisman, Joseph M. Ready, Atsushi Hasuoka, Catherine J. Smith, John L. Wood

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


A highly stereoselective total synthesis of the alkaloid natural product welwitindolinone A isonitrile has been completed. The synthesis utilizes a chloronium ion mediated semi-pinacol rearrangement to simultaneously install the C10 quaternary center and neopentyl chlorine and a novel anionic cyclization to construct the spiro-oxindole with complete stereocontrol.

Original languageEnglish (US)
Pages (from-to)1448-1449
Number of pages2
JournalJournal of the American Chemical Society
Issue number5
StatePublished - Feb 8 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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