@article{a7f7459b861b4641863ba4bd64c7bbf5,
title = "Total synthesis and biological evaluation of apicularen A and synthetic analogs",
abstract = "The first total synthesis of the potent cytostatic agent apicularen A is described along with the synthesis of the corresponding C11-epimers and side chain modified congeners. Growth inhibition experiments with the human melanoma cancer cell line SK-MEL-5 revealed an important role for the unusual N-acyl enamide side chain.",
author = "Ashoke Bhattacharjee and Seguil, {Olga R.} and {De Brabander}, {Jef K.}",
note = "Funding Information: Financial support was provided by the Robert A. Welch Foundation and junior faculty awards administered through the Howard Hughes Medical Institute and the University of Texas Southwestern Medical Center. We are grateful to Dr. Rolf Jansen (Geselschaft f{\"u}r Biotechnologische Forschung) for an authentic sample and NMR spectra of 1 , and Dr. Michael G. Roth and Maria G. Kosfiszer for assistance with the cell-based assays. ",
year = "2001",
month = feb,
day = "12",
doi = "10.1016/S0040-4039(00)02245-0",
language = "English (US)",
volume = "42",
pages = "1217--1220",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "7",
}