Topical Clindamycin Therapy for Acne Vulgaris: A Cooperative Clinical Study

Larry E. Becker, Paul R. Bergstresser, David A. Whiting, William E. Clendenning, Richard L. Dobson, William P. Jordan, Edward Abell, Lloyd A. Lezotte, Peter E. Pochi, Jerome L. Shupack, Robert B. Sigafoes, Richard B. Stoughton, John J. Voorhees

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Eleven institutions participated in an eight-week controlled clinical study to evaluate treatment of acne vulgaris with topical clindamycin hydrochloride and clindamycin phosphate. Three hundred fifty-eight patients with comparable baseline pustule, papule, and nodule counts applied 1% clindamycin hydrochloride, 1% clindamycin phosphate, or a hydroalcoholic vehicle twice daily. Every two weeks, lesions were counted, and patients' evaluations of their acne conditions were scored. By week 8, pustule and papule counts in the groups who were receiving clindamycin were significantly lower than those in the group receiving placebo. Also, more patients who were receiving clindamycin thought their acne improved by week 8 (with significantly higher change-in-acne scores) than did the patients receiving placebo. Patients receiving clindamycin reported 12 episodes of diarrhea; only one episode was considered to be treatment related. These results substantiate the clinical impession that topical clindamycin is effective treatment for acne.

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
JournalArchives of Dermatology
Issue number8
StatePublished - Aug 1981

ASJC Scopus subject areas

  • Dermatology


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