TY - JOUR
T1 - Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
AU - Pasare, Chandrashekhar
AU - Medzhitov, Ruslan
PY - 2003/2/14
Y1 - 2003/2/14
N2 - Toll-like receptors (TLRS) control activation of adaptive immune responses by antigen-presenting cells (APCs). However, initiation of adaptive immune responses is also controlled by regulatory T cells (TR cells), which act to prevent activation of autoreactive T cells. Here we describe a second mechanism of immune induction by TLRs, which is independent of effects on costimulation. Microbial induction of the Toll pathway blocked the suppressive effect of CD4+CD25+ TR cells, allowing activation of pathogen-specific adaptive immune responses. This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products.
AB - Toll-like receptors (TLRS) control activation of adaptive immune responses by antigen-presenting cells (APCs). However, initiation of adaptive immune responses is also controlled by regulatory T cells (TR cells), which act to prevent activation of autoreactive T cells. Here we describe a second mechanism of immune induction by TLRs, which is independent of effects on costimulation. Microbial induction of the Toll pathway blocked the suppressive effect of CD4+CD25+ TR cells, allowing activation of pathogen-specific adaptive immune responses. This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products.
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U2 - 10.1126/science.1078231
DO - 10.1126/science.1078231
M3 - Article
C2 - 12532024
AN - SCOPUS:0037436119
SN - 0036-8075
VL - 299
SP - 1033
EP - 1036
JO - Science
JF - Science
IS - 5609
ER -