Abstract
Toxoplasma gondii and other apicomplexan parasites are widely distributed obligate intracellular protozoa. A critical host mediator produced in response to T. gondii infection is IL-12. This cytokine is synthesized by dendritic cells, macrophages and neutrophils and plays a pivotal role in the production of IFN-γ, which in turn activates anti-microbial effector cells. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of IL-12 have been identified and characterized. Among these receptors the Toll-like receptor (TLR) family can recognize all classes of pathogens and induce different types of immune responses. In the following review, I summarize the evidence for specific TLR function in host resistance to T. gondii.
Original language | English (US) |
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Pages (from-to) | 17-21 |
Number of pages | 5 |
Journal | Immunology Letters |
Volume | 119 |
Issue number | 1-2 |
DOIs | |
State | Published - Aug 15 2008 |
Keywords
- Dendritic cells
- IFN-γ
- IL-12
- TLR11
- TLR2, MyD88
- Toll-like receptors
- Toxoplasma gondii
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology