TY - JOUR
T1 - Toll-like receptors and acquired immunity
AU - Pasare, Chandrashekhar
AU - Medzhitov, Ruslan
PY - 2004/2
Y1 - 2004/2
N2 - Toll-like receptors are a family of pattern recognition receptors (PRRs) that evolved to detect microbial infection. These receptors recognize conserved molecular products derived from different classes of microorganisms, including Gram-positive and -negative bacteria, fungi, protozoa and viruses. Following recognition of ligands TLRs initiate signaling events that result in acute innate responses. In addition, TLRs are responsible for initiation of adaptive immune responses against pathogen-derived antigens primarily through triggering dendritic cell activation. Control of adaptive immunity by TLRs is a complex phenomenon and much needs to be understood about how different TLRs tailor the outcome of adaptive immune responses to the advantage of the host. Although TLRs have evolved to induce protective immune responses, under some circumstances, activation of these receptors may lead to autoimmune diseases.
AB - Toll-like receptors are a family of pattern recognition receptors (PRRs) that evolved to detect microbial infection. These receptors recognize conserved molecular products derived from different classes of microorganisms, including Gram-positive and -negative bacteria, fungi, protozoa and viruses. Following recognition of ligands TLRs initiate signaling events that result in acute innate responses. In addition, TLRs are responsible for initiation of adaptive immune responses against pathogen-derived antigens primarily through triggering dendritic cell activation. Control of adaptive immunity by TLRs is a complex phenomenon and much needs to be understood about how different TLRs tailor the outcome of adaptive immune responses to the advantage of the host. Although TLRs have evolved to induce protective immune responses, under some circumstances, activation of these receptors may lead to autoimmune diseases.
KW - Autoimmune
KW - Receptor
KW - TLR
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U2 - 10.1016/j.smim.2003.10.006
DO - 10.1016/j.smim.2003.10.006
M3 - Article
C2 - 14751760
AN - SCOPUS:0742324857
SN - 1044-5323
VL - 16
SP - 23
EP - 26
JO - Seminars in Immunology
JF - Seminars in Immunology
IS - 1
ER -