Toll-like receptor signaling and its relevance to intestinal inflammation

Elke Cario, Daniel K. Podolsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution

29 Scopus citations


This review discusses the current progress in the understanding of how commensal-mediated activation of toll-like receptors (TLRs) may be involved in the regulation of physiological and pathophysiological processes of the intestinal mucosa including tissue regeneration and inflammation. While regulation of TLRs and their downstream signaling mediators might be used to prevent and treat inflammatory bowel diseases, paradoxically, at this time, it remains uncertain whether this would be more effectively accomplished by enhancing or inhibiting these pathways.

Original languageEnglish (US)
Title of host publicationInflammatory Bowel Disease
Subtitle of host publicationGenetics, Barrier Function, Immunologic Mechanisms, and Microbial Pathways
PublisherBlackwell Publishing Inc.
Number of pages7
ISBN (Print)1573315680, 9781573315685
StatePublished - Jan 1 2006

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Host defense
  • Inflammatory bowel diseases
  • Innate immunity
  • Intestinal epithelium
  • Resident microflora
  • Therapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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