TY - JOUR
T1 - To be or not to be? How selective autophagy and cell death govern cell fate
AU - Green, Douglas R.
AU - Levine, Beth
N1 - Funding Information:
The authors thank Haley Harrington for assistance with manuscript preparation and Angela Diehl for expert scientific illustration. B.L. is supported by NIH R01 CA109618 and CPRIT grant RP120718-P1. D.R.G. is supported by NIH R01 AI40646, AI47891, AI44828, CA169291, and GM 096208.
PY - 2014/3/27
Y1 - 2014/3/27
N2 - The health of metazoan organisms requires an effective response to organellar and cellular damage either by repair of such damage and/or by elimination of the damaged parts of the cells or the damaged cell in its entirety. Here, we consider the progress that has been made in the last few decades in determining the fates of damaged organelles and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery. We further discuss the ways in which the autophagy machinery may impact the clearance and consequences of dying cells for host physiology. Failure in the proper removal of damaged organelles and/or damaged cells by selective autophagy and cell death processes is likely to contribute to developmental abnormalities, cancer, aging, inflammation, and other diseases.
AB - The health of metazoan organisms requires an effective response to organellar and cellular damage either by repair of such damage and/or by elimination of the damaged parts of the cells or the damaged cell in its entirety. Here, we consider the progress that has been made in the last few decades in determining the fates of damaged organelles and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery. We further discuss the ways in which the autophagy machinery may impact the clearance and consequences of dying cells for host physiology. Failure in the proper removal of damaged organelles and/or damaged cells by selective autophagy and cell death processes is likely to contribute to developmental abnormalities, cancer, aging, inflammation, and other diseases.
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U2 - 10.1016/j.cell.2014.02.049
DO - 10.1016/j.cell.2014.02.049
M3 - Review article
C2 - 24679527
AN - SCOPUS:84897143522
SN - 0092-8674
VL - 157
SP - 65
EP - 75
JO - Cell
JF - Cell
IS - 1
ER -