TY - JOUR
T1 - TLX
T2 - A master regulator for neural stem cell maintenance and neurogenesis
AU - Islam, Mohammed M.
AU - Zhang, Chun Li
N1 - Funding Information:
We would like to thank Derek K. Smith for critical reading and helpful comments on the manuscript. This work was supported by the Whitehall Foundation ( 2009-12-05 ), the Welch Foundation ( I-1724 ), the Ellison Medical Foundation ( AG-NS-0753-11 ), the American Heart Association ( 09SDG2260602 ), and the NIH grants ( 1DP2OD006484 and R01NS070981 ; to C.-L.Z.).
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is specifically localized to the neurogenic regions of the forebrain and retina throughout development and adulthood. TLX regulates the expression of genes involved in multiple pathways, such as the cell cycle, DNA replication, and cell adhesion. These roles are primarily performed through the transcriptional repression or activation of downstream target genes. Emerging evidence suggests that the misregulation of TLX might play a role in the onset and progression of human neurological disorders making this factor an ideal therapeutic target. Here, we review the current understanding of TLX function, expression, regulation, and activity significant to NSC maintenance, adult neurogenesis, and brain plasticity. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
AB - The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is specifically localized to the neurogenic regions of the forebrain and retina throughout development and adulthood. TLX regulates the expression of genes involved in multiple pathways, such as the cell cycle, DNA replication, and cell adhesion. These roles are primarily performed through the transcriptional repression or activation of downstream target genes. Emerging evidence suggests that the misregulation of TLX might play a role in the onset and progression of human neurological disorders making this factor an ideal therapeutic target. Here, we review the current understanding of TLX function, expression, regulation, and activity significant to NSC maintenance, adult neurogenesis, and brain plasticity. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
KW - NR2E1
KW - Neural stem cell
KW - Neurogenesis
KW - Nuclear receptor
KW - TLX
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U2 - 10.1016/j.bbagrm.2014.06.001
DO - 10.1016/j.bbagrm.2014.06.001
M3 - Review article
C2 - 24930777
AN - SCOPUS:84921062069
SN - 1874-9399
VL - 1849
SP - 210
EP - 216
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
IS - 2
ER -