Tlr4: Central component of the sole mammalian LPS sensor

Research output: Contribution to journalReview articlepeer-review

648 Scopus citations


Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalCurrent Opinion in Immunology
Issue number1
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Tlr4: Central component of the sole mammalian LPS sensor'. Together they form a unique fingerprint.

Cite this