@article{738e9253dc4c410e8b9241a9b65d339c,
title = "Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes",
abstract = "Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks{\textquoteright} postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.",
author = "{for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network} and Harmon, {Heidi M.} and Jensen, {Erik A.} and Sylvia Tan and Chaudhary, {Aasma S.} and Slaughter, {Jonathan L.} and Bell, {Edward F.} and Wyckoff, {Myra H.} and Hensman, {Angelita M.} and Sokol, {Gregory M.} and DeMauro, {Sara B.} and Caplan, {Michael S.} and Laptook, {Abbott R.} and Martin Keszler and Vohr, {Betty R.} and Barbara Alksninis and Basso, {Kristin M.} and Robert Burke and Melinda Caskey and Katharine Johnson and Keszler, {Mary Lenore} and Knoll, {Andrea M.} and Leach, {Theresa M.} and Emilee Little and McGowan, {Elisabeth C.} and Elisa Vieira and Watson, {Victoria E.} and Suzy Ventura and Walsh, {Michele C.} and Hibbs, {Anna Maria} and Wilson-Costello, {Deanne E.} and Newman, {Nancy S.} and Payne, {Allison H.} and Siner, {Bonnie S.} and Monika Bhola and Gulgun Yalcinkaya and Truog, {William E.} and Pallotto, {Eugenia K.} and Kilbride, {Howard W.} and Cheri Gauldin and Anne Holmes and Kathy Johnson and Allison Scott and Kurt Schibler and Donovan, {Edward F.} and Cathy Grisby and Kate Bridges and Sanchez, {Pablo J.} and Brion, {Luc P.} and Heyne, {Roy J.} and Rosenfeld, {Charles R.}",
note = "Funding Information: Acknowledgements The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Center for Research Resources, and the National Center for Advancing Translational Sciences provided grant support for the Neonatal Research Network{\textquoteright}s Generic Database and Follow-up Studies through cooperative agreements. While NICHD staff did have input into the study design, conduct, analysis, and manuscript drafting, the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Data collected at participating sites of the NICHD Neonatal Research Network (NRN) were transmitted to RTI International, the data coordinating center (DCC) for the network, which stored, managed and analyzed the data for this study. On behalf of the NRN, AD (DCC Principal Investigator) and Douglas Kendrick (DCC Statistician) had full access to all the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2020",
month = apr,
day = "1",
doi = "10.1038/s41372-020-0594-4",
language = "English (US)",
volume = "40",
pages = "616--627",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "4",
}