Time-resolved fluorescence for breast cancer detection using an octreotate-indocyanine green derivative dye conjugate

Laura A. Sordillo, B. B. Das, Yang Pu, Kexian Liang, Giovanni Milione, Peter P. Sordillo, Sam Achilefu, R. R. Alfano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations


Time-resolved fluorescence was used to investigate malignant and normal adjacent breast tissues stained with a conjugate of indocyanine green and octreotate. A marked increase in fluorescence lifetime intensity was seen in the breast cancer sample compared to the normal sample. The fluorescent lifetimes were also investigated and showed similar fluorescence decay curves in stained malignant and normal breast tissue. These results confirm that somatostatin receptors occur on human breast carcinomas, suggest that the presence of somatostatin receptors should be investigated as a marker of breast cancer aggressiveness, and suggest that this conjugate might be used to detect the presence of residual breast cancer after surgery, allowing better assessment of tumor margins and reducing the need for second or repeat biopsies in selected patients. These results may also provide clues for designing future treatment options for breast cancer patients.

Original languageEnglish (US)
Title of host publicationOptical Biopsy XI
StatePublished - 2013
Externally publishedYes
EventConference on Optical Biopsy XI - San Francisco, CA, United States
Duration: Feb 5 2013Feb 6 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceConference on Optical Biopsy XI
Country/TerritoryUnited States
CitySan Francisco, CA


  • breast carcinoma
  • cancer detection
  • cypate
  • cytate
  • fluorescence spectroscopy
  • fluorescent dye
  • human tissue
  • indocyanine green
  • octreotide
  • time-resolved spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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