TY - JOUR
T1 - Thyroid Cancer Bone Metastasis
T2 - Survival and Genomic Characteristics of a Large Tertiary Care Cohort
AU - Kondraciuk, Jessica D.
AU - Rice, Samuel L.
AU - Zhou, Xiaosun
AU - Gharzeddine, Karem
AU - Knezevic, Andrea
AU - Spratt, Daniel E.
AU - Sabra, Mona
AU - Larson, Steven M.
AU - Grewal, Ravinder K.
AU - Osborne, Joseph R.
N1 - Funding Information:
This study was supported by R01 CA201250-01A1 "124I-NaI PET: Building block for precision medicine in metastatic thyroid cancer" Grant (JRO, RKG, SML) as well as by the Center for Targeted Radioimmunotherapy and Diagnosis and the Ludwig Center for Cancer Immunotherapy. This research was also funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748. None declared to all authors.
Funding Information:
Conflicts of interest and sources of funding: This study was supported by R01 CA201250-01A1 “124I-NaI PET: Building block for precision medicine in metastatic thyroid cancer” Grant (JRO, RKG, SML) as well as by the Center for Targeted Radioimmunotherapy and Diagnosis and the Ludwig Center for Cancer Immunotherapy. This research was also funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748. None declared to all authors.
Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Purpose Bone metastasis (BM) in differentiated thyroid cancer (DTC) is the second most common site of metastasis after lung. Bone metastases are associated with worse prognosis in DTC. In this study, we examined risk factors for overall survival in patients with BM and for the first time explore the pattern of genomic alterations in DTC BM. Patients and Methods A Health Insurance Portability and Accountability Act (HIPAA) compliant, institutional review board-approved retrospective evaluation of the medical record was performed for all patients treated at a single institution for thyroid cancer over a 16-year period. Seventy-four patients met inclusion criteria. Multiple prognostic factors including age, sex, genes, radioactive iodine, and radiation or kinase inhibitor therapies were analyzed. Univariate and multivariate analyses were performed. Results Treatment with external beam radiation was found to significantly increase survival (P = 0.03). The 5-year survival rate was 59% and median survival was 92 months. Patients who developed bone metastasis earlier tend to live longer (P = 0.06). The presence of TERT and BRAF mutations did not significantly worsen the prognosis (P = 0.10). Conclusion Patients with DTC can benefit from early treatment with external beam radiation therapy, especially those who develop bone metastasis within 3 years of primary TC diagnosis. Kinase inhibitor treatment tended to prolong survival but not in a statistically significant manner. Sex, age, and TERT or BRAF genetic mutations did not significantly affect the prognosis.
AB - Purpose Bone metastasis (BM) in differentiated thyroid cancer (DTC) is the second most common site of metastasis after lung. Bone metastases are associated with worse prognosis in DTC. In this study, we examined risk factors for overall survival in patients with BM and for the first time explore the pattern of genomic alterations in DTC BM. Patients and Methods A Health Insurance Portability and Accountability Act (HIPAA) compliant, institutional review board-approved retrospective evaluation of the medical record was performed for all patients treated at a single institution for thyroid cancer over a 16-year period. Seventy-four patients met inclusion criteria. Multiple prognostic factors including age, sex, genes, radioactive iodine, and radiation or kinase inhibitor therapies were analyzed. Univariate and multivariate analyses were performed. Results Treatment with external beam radiation was found to significantly increase survival (P = 0.03). The 5-year survival rate was 59% and median survival was 92 months. Patients who developed bone metastasis earlier tend to live longer (P = 0.06). The presence of TERT and BRAF mutations did not significantly worsen the prognosis (P = 0.10). Conclusion Patients with DTC can benefit from early treatment with external beam radiation therapy, especially those who develop bone metastasis within 3 years of primary TC diagnosis. Kinase inhibitor treatment tended to prolong survival but not in a statistically significant manner. Sex, age, and TERT or BRAF genetic mutations did not significantly affect the prognosis.
KW - external beam radiation
KW - genomic characteristics
KW - thyroid cancer bone metastasis
UR - http://www.scopus.com/inward/record.url?scp=85069269656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069269656&partnerID=8YFLogxK
U2 - 10.1097/RLU.0000000000002626
DO - 10.1097/RLU.0000000000002626
M3 - Article
C2 - 31274625
AN - SCOPUS:85069269656
SN - 0363-9762
VL - 44
SP - E465-E471
JO - Clinical nuclear medicine
JF - Clinical nuclear medicine
IS - 8
ER -