Thrombopoietic status of patients on haemodialysis

Taha Bat; Betul E. Bat; Ahmed El-Moghraby; Samir Patel; Xingmin Feng; Cynthia E. Dunbar; Erdal Sarac

doi:10.1111/bjh.13918

Thrombopoietic status of patients on haemodialysis

Taha Bat, Betul E. Bat, Ahmed El-Moghraby, Samir Patel, Xingmin Feng, Cynthia E. Dunbar, Erdal Sarac

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Thrombocytopenia is a potential dialysis-related treatment complication. Developments in bio-compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre- and post- haemodialysis in a cohort of 45 well-characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.

Original language	English (US)
Pages (from-to)	954-957
Number of pages	4
Journal	British Journal of Haematology
Volume	172
Issue number	6
DOIs	https://doi.org/10.1111/bjh.13918
State	Published - Mar 1 2016
Externally published	Yes

Keywords

Absolute immature platelet number
Haemodialysis
IL1A (IL1α)
Immature platelet fraction
Thrombopoietin

ASJC Scopus subject areas

Hematology

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10.1111/bjh.13918

Cite this

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title = "Thrombopoietic status of patients on haemodialysis",

abstract = "Thrombocytopenia is a potential dialysis-related treatment complication. Developments in bio-compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre- and post- haemodialysis in a cohort of 45 well-characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.",

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AU - Bat, Taha

AU - Bat, Betul E.

AU - El-Moghraby, Ahmed

AU - Patel, Samir

AU - Feng, Xingmin

AU - Dunbar, Cynthia E.

AU - Sarac, Erdal

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Thrombocytopenia is a potential dialysis-related treatment complication. Developments in bio-compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre- and post- haemodialysis in a cohort of 45 well-characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.

AB - Thrombocytopenia is a potential dialysis-related treatment complication. Developments in bio-compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre- and post- haemodialysis in a cohort of 45 well-characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.

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KW - Immature platelet fraction

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Thrombopoietic status of patients on haemodialysis

Abstract

Keywords

ASJC Scopus subject areas

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