Three infants who have perioral and acral skin lesions

Douglas Leonard, Rafet Koca, Ceyda Acun, Saniye Çinar, Emel Eştürk, Gonca Üstündaǧ, Sarah Herron, Mark M. Butterfly, Joseph A. Zenel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Zinc is an essential trace metal whose deficiency leads to growth retardation; an eczematous, vesiculobullous, and pustular rash over the perioral, perianal, and acral areas; alopecia; diarrhea; secondary bacterial and fungal infections; and neurologic, behavioral, and cognitive impairment. Zinc deficiency can result from a zinc-deficient diet, malabsorption (as in AE), a genetic disorder of intestinal zinc uptake, and increased losses. Oral zinc supplementation reverses most signs and symptoms of zinc deficiency, regardless of cause.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalPediatrics in review
Issue number8
StatePublished - Aug 2007

ASJC Scopus subject areas

  • General Medicine


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