Three-dimensional cine MRI in free-breathing infants and children with congenital heart disease

Achim Seeger, Michael C. Fenchel, Gerald F. Greil, Petros Martirosian, Ulrich Kramer, Christiane Bretschneider, Joerg Doering, Claus D. Claussen, Ludger Sieverding, Stephan Miller

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: Patients with congenital heart disease frequently have complex cardiac and vascular malformations requiring detailed non-invasive diagnostic evaluation including functional parameters. Objective: To evaluate the morphological and functional information provided by a novel 3-D cine steady-state free-precession (SSFP) sequence. Materials and methods: Twenty consecutive children (mean age 2.2 years, nine boys) were examined using a 1.5-T MR system including 2-D cine gradient-recalled-echo sequences, static 3-D SSFP and 3-D cine SSFP sequences. Results: Measurement of ventricular structures and volumes showed close agreement between the 3-D cine SSFP sequence and the 2-D cine gradient-recalled-echo and static 3-D SSFP sequences (left ventricular volumes mean difference 1.0-1.9 ml and 8.8-11.4%, respectively; right ventricular volumes 1.7-2.1 ml and 9.9-16.9%, respectively). No systematic bias was observed. Conclusion: 3-D cine MRI provides anatomic as well as functional information with sufficient spatial and temporal resolution in free-breathing infants with congenital heart disease.

Original languageEnglish (US)
Pages (from-to)1333-1342
Number of pages10
JournalPediatric radiology
Issue number12
StatePublished - Dec 2009


  • 3D cine
  • 4D
  • Cardiac
  • Cardiac MRI
  • Children
  • Cine
  • Congenital heart disease
  • MRI

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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