Three-dimensional bioluminescence tomography with model-based reconstruction

Xuejun Gu, Qizhi Zhang, Lyndon Larcom, Huabei Jiang

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.

Original languageEnglish (US)
Pages (from-to)3996-4000
Number of pages5
JournalOptics Express
Issue number17
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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