Thinking outside the Osp(G) - Kinase activation by E2-ubiquitin

Maarten F. De Jong; Neal M. Alto

doi:10.1002/embj.201387606

Thinking outside the Osp(G) - Kinase activation by E2-ubiquitin

Maarten F. De Jong, Neal M. Alto

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

OspG is a secreted effector kinase from the human pathogen Shigella that is required for the reduction of immune responses during Shigella infection. A new study in The EMBO Journal provides a co-crystal structure of OspG bound to UbcH5c∼Ub, revealing how a bacterial kinase can be activated by the host ubiquitin conjugation machinery. These results provide molecular insight into an enigmatic microbial virulence factor that thwarts the host immune surveillance system to cause disease.

Original language	English (US)
Pages (from-to)	403-404
Number of pages	2
Journal	EMBO Journal
Volume	33
Issue number	5
DOIs	https://doi.org/10.1002/embj.201387606
State	Published - Mar 3 2014

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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abstract = "OspG is a secreted effector kinase from the human pathogen Shigella that is required for the reduction of immune responses during Shigella infection. A new study in The EMBO Journal provides a co-crystal structure of OspG bound to UbcH5c∼Ub, revealing how a bacterial kinase can be activated by the host ubiquitin conjugation machinery. These results provide molecular insight into an enigmatic microbial virulence factor that thwarts the host immune surveillance system to cause disease.",

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Thinking outside the Osp(G) - Kinase activation by E2-ubiquitin

Abstract

ASJC Scopus subject areas

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