Thiazolidinediones regulate adipose lineage dynamics

Wei Tang; Daniel Zeve; Jin Seo; A. Young Jo; Jonathan M. Graff

doi:10.1016/j.cmet.2011.05.012

Thiazolidinediones regulate adipose lineage dynamics

Wei Tang, Daniel Zeve, Jin Seo, A. Young Jo, Jonathan M. Graff

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.

Original language	English (US)
Pages (from-to)	116-122
Number of pages	7
Journal	Cell Metabolism
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2011.05.012
State	Published - Jul 6 2011

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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title = "Thiazolidinediones regulate adipose lineage dynamics",

abstract = "White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.",

author = "Wei Tang and Daniel Zeve and Jin Seo and Jo, {A. Young} and Graff, {Jonathan M.}",

note = "Funding Information: We thank Luis Parada, Michelle Tallquist, Shawna Kennedy, and members of the Graff Lab. This study was supported by NIH, NIDDK (R01 DK066556, R01 DK064261, and R01 DK088220), and the AHA postdoctoral (W.T. and J.S.) and predoctoral (D.Z.) fellowship grants. J.M.G. is a cofounder and shareholder of Reata Pharmaceuticals. ",

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doi = "10.1016/j.cmet.2011.05.012",

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AU - Tang, Wei

AU - Zeve, Daniel

AU - Seo, Jin

AU - Jo, A. Young

AU - Graff, Jonathan M.

N1 - Funding Information: We thank Luis Parada, Michelle Tallquist, Shawna Kennedy, and members of the Graff Lab. This study was supported by NIH, NIDDK (R01 DK066556, R01 DK064261, and R01 DK088220), and the AHA postdoctoral (W.T. and J.S.) and predoctoral (D.Z.) fellowship grants. J.M.G. is a cofounder and shareholder of Reata Pharmaceuticals.

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N2 - White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.

AB - White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.

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Thiazolidinediones regulate adipose lineage dynamics

Abstract

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