Thiazide diuretics and calcium metabolism

Stewart Middler, Charles Y C Pak, Ferid Murad, Frederic C. Bartter

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Thiazide diuretics reduce urinary excretion of calcium by about 40% in patients with intact parathyroid glands (normal parathyroid function or primary hyperparathyroidism). Despite equivalent sodium losses, thiazide diuretics do not lower calcium excretion in patients with hypoparathyroidism. Thiazide diuretics diminish hydroxyproline excretion by about 22%, and they do not affect 3′5′-cyclic AMP excretion in subjects with intact parathyroid glands. These findings, together with additional data in the literature, suggest that thiazides may potentiate the renal action of parathyroid hormone, resulting in retention of calcium and partial suppression of parathyroid hormone secretion.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
Issue number2
StatePublished - Feb 1973

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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