Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

Cassandra E. Callmann; Christopher V. Barback; Matthew P. Thompson; David J. Hall; Robert F. Mattrey; Nathan C. Gianneschi

doi:10.1002/adma.201501803

Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

Cassandra E. Callmann, Christopher V. Barback, Matthew P. Thompson, David J. Hall, Robert F. Mattrey, Nathan C. Gianneschi

Research output: Contribution to journal › Article › peer-review

211 Scopus citations

Abstract

An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.

Original language	English (US)
Pages (from-to)	4611-4615
Number of pages	5
Journal	Advanced Materials
Volume	27
Issue number	31
DOIs	https://doi.org/10.1002/adma.201501803
State	Published - Aug 1 2015

Keywords

drug delivery
enzyme-responsive
nanomaterials
self-assembly
stimuli-responsive

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201501803

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title = "Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors",

abstract = "An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.",

keywords = "drug delivery, enzyme-responsive, nanomaterials, self-assembly, stimuli-responsive",

author = "Callmann, {Cassandra E.} and Barback, {Christopher V.} and Thompson, {Matthew P.} and Hall, {David J.} and Mattrey, {Robert F.} and Gianneschi, {Nathan C.}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

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doi = "10.1002/adma.201501803",

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AU - Callmann, Cassandra E.

AU - Barback, Christopher V.

AU - Thompson, Matthew P.

AU - Hall, David J.

AU - Mattrey, Robert F.

AU - Gianneschi, Nathan C.

PY - 2015/8/1

Y1 - 2015/8/1

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AB - An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.

KW - drug delivery

KW - enzyme-responsive

KW - nanomaterials

KW - self-assembly

KW - stimuli-responsive

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Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

Abstract

Keywords

ASJC Scopus subject areas

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