The 'well tempered' diuretic renogram: A standard method to examine the asymptomatic neonate with hydronephrosis or hydroureteronephrosis

Craig A Peters, J. Mandell, T. Treves, M. Zaontz, L. Zeigler, M. Maizels, E. M. Reisman, C. Firlit, S. Flom, J. J. Conway, S. Weiss, R. Shore, J. Elder, F. Miraldi, C. Reitelman, R. Dector, D. Eggli, E. Shapiro, R. Gonzalez

Research output: Contribution to journalReview articlepeer-review

252 Scopus citations


Perinatal hydronephrosis (HN) and hydroureteronephrosis (HUN) are recognized more frequently as the routine use of prenatal ultrasonography increases. The decision-making process for those instances of urinary tract dilatation that require surgical correction and those that do not is based in part on the findings of diuresis renography. The methodology for performing this test has differed among nuclear medicine practitioners and the surgical findings are occasionally discrepant from the diuretic renogram interpretation. Consequently, the Society of Fetal Urology (SFU) and the Pediatric Nuclear Medicine Council (PNMC) of the Society of Nuclear Medicine met to develop by consensus a more uniform methodology. A standard method has been agreed upon for the following facets of diuretic renography: patient preparation (hydration and bladder catheterization), diuresis renography technique (radiopharmaceutical used, patient position during examination, data acquisition parameters, diuretic pharmaceutical and dosage, time of injection and regions of interest to monitor diuretic effect), and data analysis (percent differential renal function, curve pattern analysis and methods of measuring diuretic response). Pooled diuresis renogram data are being collected for analysis for correlation with surgical results and clinical outcomes to determine the most appropriate information to be derived from the diuretic renogram in neonates with HN and HUN.

Original languageEnglish (US)
Pages (from-to)2047-2051
Number of pages5
JournalJournal of Nuclear Medicine
Issue number11
StatePublished - 1992

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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