TY - JOUR
T1 - The variable number of tandem repeat polymorphism of platelet glycoprotein Ibα and risk of coronary heart disease
AU - Afshar-Kharghan, Vahid
AU - Matijevic-Aleksic, Nevenka
AU - Ahn, Chul
AU - Boerwinkle, Eric
AU - Wu, Kenneth K.
AU - López, José A.
PY - 2004/2/1
Y1 - 2004/2/1
N2 - Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ibα, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ibα and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ibα is different among whites and African Americans. The B allele (with 3 repeats) of GP Ibα is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes.
AB - Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ibα, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ibα and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ibα is different among whites and African Americans. The B allele (with 3 repeats) of GP Ibα is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes.
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U2 - 10.1182/blood-2003-05-1502
DO - 10.1182/blood-2003-05-1502
M3 - Article
C2 - 14592833
AN - SCOPUS:1642459358
SN - 0006-4971
VL - 103
SP - 963
EP - 965
JO - Blood
JF - Blood
IS - 3
ER -