@article{6e87153aecbf43f6ae706b451da57c19,
title = "The vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde induces aberrant mitotic progression and enhances radio-sensitivity accompanying suppression the expression of PLK1 in esophageal squamous cell carcinoma",
abstract = "Esophageal squamous cell carcinoma (ESCC) is the most common form of esophageal cancer in China. Since chemotherapy is the standard clinical intervention for advanced ESCC, the development of highly effective and minimal/non-toxic drugs is essential to improve the clinical outcome and prognosis of the patients. A novel derivative of vanillin, 6-bromine-5-hydroxy-4-methoxybenzaldehyde (BVAN08), has been recently reported to activate different cell death pathways in cancer cells. In this study, we demonstrate that BVAN08 exhibits a potent anti-proliferation effect on ESCC cells (TE-1 and ECA-109) by inhibiting the expression of PLK1, an important mitotic kinase. Consistent with this, BVAN08 induces mitotic arrest and chromosomal misalignment in ESCC cells. The disruption of microtubule nucleation around centrosomes is also observed in BVAN08 treated ESCC cells. Furthermore, BVAN08 enhances radio-sensitivity of ESCC cells by prolonging DNA damage repair. These findings underscore the potential value of BVAN08 in cancer therapeutics and demonstrate the underlying mechanism by which BVAN08 induces mitotic catastrophe and enhances radio-sensitivity in ESCC cells.",
keywords = "BVAN08, Microtubule assembly, Mitotic catastrophe, PLK1, Radio-sensitivity",
author = "Gu, {Meng Meng} and Ming Li and Dexuan Gao and Liu, {Lang Huan} and Yue Lang and Yang, {Si Ming} and Hongling Ou and Bo Huang and Zhou, {Ping Kun} and Shang, {Zeng Fu}",
note = "Funding Information: This work was supported by the National Natural Science Foundation of China [grant numbers 81530085, 81472919, 81573079, 81673091], the Natural Science Foundation of Jiangsu Province of China [grant number BK20131149], the Six Talent Peaks Project of Jiangsu Province of China [grant number WSN095], the Suzhou Administration of Science and Technology [grant number SYS201360], Suzhou Key Medical Center [grant number SZZX201506], the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection. Funding Information: This work was supported by the National Natural Science Foundation of China [grant numbers 81530085 , 81472919 , 81573079 , 81673091 ], the Natural Science Foundation of Jiangsu Province of China [grant number BK20131149 ], the Six Talent Peaks Project of Jiangsu Province of China [grant number WSN095 ], the Suzhou Administration of Science and Technology [grant number SYS201360 ], Suzhou Key Medical Center [grant number SZZX201506 ], the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = jun,
day = "1",
doi = "10.1016/j.taap.2018.04.021",
language = "English (US)",
volume = "348",
pages = "76--84",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
}