TY - JOUR
T1 - The trk proto-oncogene product
T2 - A signal transducing receptor for nerve growth factor
AU - Kaplan, David R.
AU - Hempstead, Barbara L.
AU - Martin-Zanca, Dionisio
AU - Chao, Moses V.
AU - Parada, Luis F.
PY - 1991
Y1 - 1991
N2 - The trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase (p140prototrk) that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of p140 prototrk in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10-9 molar. The identification of p140prototrk as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF.
AB - The trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase (p140prototrk) that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of p140 prototrk in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10-9 molar. The identification of p140prototrk as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF.
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U2 - 10.1126/science.1850549
DO - 10.1126/science.1850549
M3 - Article
C2 - 1850549
AN - SCOPUS:0025735392
SN - 0036-8075
VL - 252
SP - 554
EP - 558
JO - Science
JF - Science
IS - 5005
ER -