The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

Jenifer Jowsey; Robert C. Hoye; Charles Y C Pak; Frederic C. Bartter

doi:10.1016/0002-9343(69)90237-x

The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

Jenifer Jowsey, Robert C. Hoye, Charles Y C Pak, Frederic C. Bartter

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.

Original language	English (US)
Pages (from-to)	17-22
Number of pages	6
Journal	The American Journal of Medicine
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0002-9343(69)90237-x
State	Published - Jul 1969

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/0002-9343(69)90237-x

Cite this

@article{2df1afdef9e9452aa33e07b339603d5f,

title = "The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies",

abstract = "Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.",

author = "Jenifer Jowsey and Hoye, {Robert C.} and Pak, {Charles Y C} and Bartter, {Frederic C.}",

note = "Funding Information: *From the Endocrinology Branch, National Heart Institute, Bethesda, Maryland, and the Mayo Clinic, Rochester, Minnesota, This investigation was supported in part by Research Grant AMO-8658 from the National Institutes of Health, Public Health Service. Requests for reprints should be addressed to Jenifer Jowsey, M.D., Section of Surgical Research (Orthopedics), Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901. Manu. script received February 11, 1969.",

year = "1969",

month = jul,

doi = "10.1016/0002-9343(69)90237-x",

language = "English (US)",

volume = "47",

pages = "17--22",

journal = "The American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

AU - Jowsey, Jenifer

AU - Hoye, Robert C.

AU - Pak, Charles Y C

AU - Bartter, Frederic C.

N1 - Funding Information: *From the Endocrinology Branch, National Heart Institute, Bethesda, Maryland, and the Mayo Clinic, Rochester, Minnesota, This investigation was supported in part by Research Grant AMO-8658 from the National Institutes of Health, Public Health Service. Requests for reprints should be addressed to Jenifer Jowsey, M.D., Section of Surgical Research (Orthopedics), Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901. Manu. script received February 11, 1969.

PY - 1969/7

Y1 - 1969/7

N2 - Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.

AB - Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.

UR - http://www.scopus.com/inward/record.url?scp=0014549286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014549286&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(69)90237-x

DO - 10.1016/0002-9343(69)90237-x

M3 - Article

C2 - 5802436

AN - SCOPUS:0014549286

SN - 0002-9343

VL - 47

SP - 17

EP - 22

JO - The American Journal of Medicine

JF - The American Journal of Medicine

IS - 1

ER -

The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this