The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

Jenifer Jowsey, Robert C. Hoye, Charles Y C Pak, Frederic C. Bartter

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalThe American Journal of Medicine
Issue number1
StatePublished - Jul 1969

ASJC Scopus subject areas

  • Medicine(all)


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