The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

Jenifer Jowsey; Robert C. Hoye; Charles Y C Pak; Frederic C. Bartter

doi:10.1016/0002-9343(69)90237-x

The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

Jenifer Jowsey, Robert C. Hoye, Charles Y C Pak, Frederic C. Bartter

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Abstract

Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.

Original language	English (US)
Pages (from-to)	17-22
Number of pages	6
Journal	The American Journal of Medicine
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0002-9343(69)90237-x
State	Published - Jul 1969

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Medicine(all)

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title = "The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies",

abstract = "Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.",

author = "Jenifer Jowsey and Hoye, {Robert C.} and Pak, {Charles Y C} and Bartter, {Frederic C.}",

note = "Funding Information: *From the Endocrinology Branch, National Heart Institute, Bethesda, Maryland, and the Mayo Clinic, Rochester, Minnesota, This investigation was supported in part by Research Grant AMO-8658 from the National Institutes of Health, Public Health Service. Requests for reprints should be addressed to Jenifer Jowsey, M.D., Section of Surgical Research (Orthopedics), Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901. Manu. script received February 11, 1969.",

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doi = "10.1016/0002-9343(69)90237-x",

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T1 - The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

AU - Jowsey, Jenifer

AU - Hoye, Robert C.

AU - Pak, Charles Y C

AU - Bartter, Frederic C.

N1 - Funding Information: *From the Endocrinology Branch, National Heart Institute, Bethesda, Maryland, and the Mayo Clinic, Rochester, Minnesota, This investigation was supported in part by Research Grant AMO-8658 from the National Institutes of Health, Public Health Service. Requests for reprints should be addressed to Jenifer Jowsey, M.D., Section of Surgical Research (Orthopedics), Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901. Manu. script received February 11, 1969.

PY - 1969/7

Y1 - 1969/7

N2 - Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.

AB - Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.

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The treatment of osteoporosis with calcium infusions. Evaluation of bone biopsies

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