The transient receptor potential superfamily of ion channels

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM, TRPP, TRPN, and TRPML subfamilies. TRP channels are widespread and have diverse functions, ranging from thermal, tactile, taste, osmolar, and fluid flow sensing to transepithelial Ca2+ and Mg2+ transport. Mutations of TRP proteins produce many renal diseases, including Mg2+ wasting, hypocalcemia, and polycystic kidney diseases. This review focuses on recent advances in the understanding of their functions.

Original languageEnglish (US)
Pages (from-to)1690-1699
Number of pages10
JournalJournal of the American Society of Nephrology
Issue number7
StatePublished - Jul 2004

ASJC Scopus subject areas

  • Nephrology


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