Abstract
Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor α (RARα) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARα fuses to the PML gene in themajority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes. As a consequence, X-RARα and RARα-X fusion genes are generated encoding aberrant chimeric proteins that exert critical oncogenic functions. Here we will integrate some of the most recent findings in APL research in a unified model and discuss some of the outstanding questions that remain to be addressed.
Original language | English (US) |
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Pages (from-to) | 85-100 |
Number of pages | 16 |
Journal | Current Topics in Microbiology and Immunology |
Volume | 313 |
State | Published - 2007 |
ASJC Scopus subject areas
- Immunology and Allergy
- Microbiology (medical)
- General Immunology and Microbiology
- Microbiology