The synthesis and chelation chemistry of DOTA - Peptide conjugates

Luis M. De León-Rodríguez, Zoltan Kovacs

Research output: Contribution to journalReview articlepeer-review

223 Scopus citations


Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid) - peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesis of DOTA - peptide conjugates, their coordination and chelation chemistry, and the biomedical applications of various DOTA - peptide conjugate metal complexes.

Original languageEnglish (US)
Pages (from-to)391-402
Number of pages12
JournalBioconjugate Chemistry
Issue number2
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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