TY - JOUR
T1 - The (social) lives, deaths, and biophysical phases of lipid droplets
AU - Henne, W. Mike
N1 - Funding Information:
W.M. Henne is supported by funds from the National Institute of General Medical Sciences ( GM119768 ), the National Institute of Diabetes and Digestive and Kidney Diseases ( DK126887 ), the Welch Foundation ( I-1873 ), the Ara Parseghian Medical Research Fund , and the UT Southwestern Endowed Scholars program .
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/6
Y1 - 2023/6
N2 - Lipid droplets (LDs) are major lipid storage organelles, sequestering energy-rich triglycerides and serving as nutrient sinks for cellular homeostasis. Observed for over a century but generally ignored, LDs are now appreciated to play key roles in organismal physiology and disease. They also form numerous functional contacts with other organelles. Here, we highlight recent studies examining LDs from distinct perspectives of their life cycle: their biogenesis, “social” life as they interact with other organelles, and deaths via lipolysis or lipophagy. We also discuss recent work showing how changes in LD lipid content alter the biophysical phases of LD lipids, and how this may fine-tune the LD protein landscape and ultimately LD function.
AB - Lipid droplets (LDs) are major lipid storage organelles, sequestering energy-rich triglycerides and serving as nutrient sinks for cellular homeostasis. Observed for over a century but generally ignored, LDs are now appreciated to play key roles in organismal physiology and disease. They also form numerous functional contacts with other organelles. Here, we highlight recent studies examining LDs from distinct perspectives of their life cycle: their biogenesis, “social” life as they interact with other organelles, and deaths via lipolysis or lipophagy. We also discuss recent work showing how changes in LD lipid content alter the biophysical phases of LD lipids, and how this may fine-tune the LD protein landscape and ultimately LD function.
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U2 - 10.1016/j.ceb.2023.102178
DO - 10.1016/j.ceb.2023.102178
M3 - Review article
C2 - 37295067
AN - SCOPUS:85161308033
SN - 0955-0674
VL - 82
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
M1 - 102178
ER -