The sigma-1 receptor: Roles in neuronal plasticity and disease

Saïd Kourrich, Tsung Ping Su, Michiko Fujimoto, Antonello Bonci

Research output: Contribution to journalReview articlepeer-review

183 Scopus citations


Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca2+ signaling. In this review, we discuss the current understanding of Sig-1R functions. Based on this, we suggest that the key cellular mechanisms linking Sig-1Rs to neurological disorders involve the translocation of Sig-1Rs from the MAM to other parts of the cell, whereby Sig-1Rs bind and modulate the activities of various ion channels, receptors, or kinases. Thus, Sig-1Rs and their associated ligands may represent new avenues for treating aspects of neurological and psychiatric diseases.

Original languageEnglish (US)
Pages (from-to)762-771
Number of pages10
JournalTrends in Neurosciences
Issue number12
StatePublished - Dec 2012


  • Binding immunoglobulin protein
  • GABA receptors
  • Glutamate receptors
  • Mitochondrion-associated ER membrane
  • Neuronal excitability
  • Voltage-gated ion channels

ASJC Scopus subject areas

  • Neuroscience(all)


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